![]() ![]() Avoid the concomitant use of drugs known to prolong the QTc interval. Pimozide is contraindicated for use with sertraline. The risk of QTc prolongation and/or ventricular arrhythmias (e.g., TdP) is increased with concomitant use of other drugs which prolong the QTc interval. Monitor phenytoin levels when initiating or titrating Zoloft. Zoloft may increase phenytoin concentrations. Phenytoin is a narrow therapeutic index drug. Propafenone, flecainide, atomoxetine, desipramine, dextromethorphan, metoprolol, nebivolol, perphenazine, thoridazine, tolterodine, venlafaxine Conversely, an increase in dosage of a CYP2D6 substrate may be needed if Zoloft is discontinued. The concomitant use of Zoloft with a CYP2D6 substrate may increase the exposure of the CYP2D6 substrate.ĭecrease the dosage of a CYP2D6 substrate if needed with concomitant Zoloft use. Monitor for adverse reactions and reduce dosage of Zoloft or other protein-bound drugs as warranted. The concomitant use of Zoloft with another drug that is highly bound to plasma protein may increase free concentrations of Zoloft or other tightly-bound drugs in plasma. Zoloft is highly bound to plasma protein. For patients taking warfarin, carefully monitor the international normalized ratio. Inform patients of the increased risk of bleeding associated with the concomitant use of Zoloft and antiplatelet agents and anticoagulants. The concurrent use of an antiplatelet agent or anticoagulant with Zoloft may potentiate the risk of bleeding. John’s Wortĭrugs that Interfere with Hemostasis (antiplatelet agents and anticoagulants) Other SSRIs, SNRIs, triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, St. If serotonin syndrome occurs, consider discontinuation of Zoloft and/or concomitant serotonergic drugs. Monitor patients for signs and symptoms of serotonin syndrome, particularly during treatment initiation and dosage increases. The concomitant use of serotonergic drugs with Zoloft increases the risk of serotonin syndrome. Increased plasma concentrations of pimozide, a drug with a narrow therapeutic index, may increase the risk of QTc prolongation and ventricular arrhythmias.Ĭoncomitant use of pimozide and Zoloft is contraindicated. Selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue Zoloft is contraindicated in patients taking MAOIs, including MAOIs such as linezolid or intravenous methylene blue. The concomitant use of SSRIs including Zoloft and MAOIs increases the risk of serotonin syndrome. Table 5: Clinically-Significant Drug Interactions with Zoloft Monoamine Oxidase Inhibitors ( MAOIs) Table 5 includes clinically significant drug interactions with Zoloft. What drugs interact with Zoloft? Clinically Significant Drug Interactions If Zoloft is discontinued abruptly, some patients experience side effects such as:Ī gradual dose reduction of Zoloft is recommended when therapy is discontinued. Important side effects are irregular heartbeats, allergic reactions and activation of mania in patients with bipolar disorder. ![]() Activation of mania in patients with bipolar disorder.Possible serious side effects of Zoloft include: What are the serious side effects of Zoloft? Increase in sweating, known as diaphoresis.The most common side effects of Zoloft are: What are the common side effects of Zoloft? Patients who are started on therapy should be closely observed for clinical worsening, suicidal thoughts, or unusual changes in behavior. Anyone considering the use of Zoloft or any other antidepressant in a child or adolescent must balance this risk with the clinical need for the antidepressant. What are the side effects of Zoloft? WARNINGĪs demonstrated in short-term studies, antidepressants increased the risk of suicidal thinking and behavior (suicidality) in children and adolescents with depression and other psychiatric disorders.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |